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Exactis Innocation, cell‑free, DNA
Miguel Alcaide, Matthew Cheung, Jack Hillman, S. Rod Rassekh, Rebecca J. Deyell, Gerald Batist, Aly Karsan, AlexanderW. Wyatt, Nathalie Johnson, DavidW. Scott7 & Ryan D. Morin1* Abstract Cell-free DNA (cfDNA) has become a comprehensive biomarker in the fields of non-invasive cancer detection and monitoring, organ transplantation, prenatal genetic testing and pathogen detection. While cfDNA samples can...
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Exactis is pleased to be working with Dr. Jonathan Spicer on a phase I interventional pilot open-label trial, using rhDNase1 as a treatment for COVID-19 positive patients. The objectives are to assess the safety and feasibility of inhaled rhDNase1 in severely ill COVID-19 patients requiring admission, to evaluate the impact of rhDNase1 in limiting progression...
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The Exactis-01 trial, a PMT sub-study “Multi-centre Observational Study to Evaluate the Clinical Utility of Returning Genomic Aberration Results Using the Oncomine Precision Assay (OPA) in Advanced or Metastatic NSCLC within the Exactis Network” will be open at several PMT sites and Princess Margaret Hospital, the PI of the study is Dr. Jason Agulnik from...
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The Exactis-03 trial “A  Phase I/II Basket Trial of the Combination of Veliparib and Navitoclax in  Women with High Grade Serous Epithelial Ovarian Cancer and Triple Negative Breast Cancer” led by Dr. Helen MacKay from Sunnybrook Hospital, will be opened across PMT Network sites and Princess Margaret Hospital. Phase I will define the dose and schedule of navitoclax that can be combined safely with...
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Sermonix Pharmaceuticals’ study “Evaluation of Lasofoxifene Versus Fulvestrant in Advanced or Metastatic ER+/HER2− Breast Cancer With an ESR1 Mutation.” The clinical trial is ongoing in the United States, and Exactis is currently performing a feasibility assessment across Canada to identify sites interested in participating in the study, if interested please contact dsalazar@exactis.ca.  https://clinicaltrials.gov/ct2/show/NCT03781063?term=sermonix&draw=2&rank=1
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Exactis is pleased to be working with Dr. Sébastien Perreault from CHU Ste-Justine on the TRAM-01 study, “ Phase 2 study of Trametinib for patients with pediatric glioma or plexiform neurofibroma with refractory tumor and activation of the MAPK/ERK pathway”. This study is led by Dr. Sébastien Perreault and the main objective is to determine...
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Our new manuscript “Discovery of a putative blood-based protein signature associated with response to ALK tyrosine kinase inhibition” is now available in Clinical Proteomics. Our research identified potential protein candidates for a blood-based prognostic signature of response to crizotinib in NSCLC patients harboring ALK fusion. https://doi.org/10.1186/s12014-020-9269-6 (Feb 2020) Publication: https://exactis.qa.simplyphp.com/2020/02/07/discovery-of-a-putative-blood-based-protein-signature-associated-with-response-to-alk-tyrosine-kinase-inhibition/
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Dear Exactis Network,  With the current and ever-evolving situation with COVID-19, we wanted to provide you with an update on our response to date and our commitment moving forward. The health, safety and well-being of participants, and our Network Team is a top priority. We are following the lead of Canadian and provincial public health authorities at this time and have been in touch daily...
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Exactis, Discovery, putative blood-based, ALK tyrosine kinase inhibition
Authors: Mathilde Couëtoux du Tertre, Maud Marques, Suzan McNamara, Karen Gambaro, Cyrla Hoffert, Lise Tremblay, Nicole Bouchard, Razvan Diaconescu, Normand Blais, Christian Couture, Vincent Pelsser, Hangjun Wang, Laura McIntosh, Valérie Hindie, Stephane Parent, Laetitia Cortes, Yannick-André Breton, Gwenael Pottiez, Pascal Croteau, Valerie Higenell, Luisa Izzi, Alan Spatz, Victor Cohen, Gerald Batist & Jason Agulnik Abstract...
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Exactis study, Proteogenomics of Colorectal Cancer Liver
Authors: Bernhard Blank-Landeshammer, Vincent R. Richard, Georgia Mitsa, Maud Marques , André LeBlanc, Laxmikanth Kollipara, Ingo Feldmann, Mathilde Couetoux du Tertre, Karen Gambaro , Suzan McNamara, Alan Spatz, René P. Zahedi, Albert Sickmann, Gerald Batist and Christoph H. Borchers Abstract Hotspot testing for activating KRAS mutations is used in precision oncology to select colorectal cancer (CRC) patients who...
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